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IBUPROFEN
Structure:
C13H18O2
Molecular Weight = 206.3
The chemical name of Ibuprofen is 2-(4-Isobutylphenyl) propionic acid. ...
Ibuprofen belongs to class of drugs called non-steroidal anti-inflammatory drugs (NSAID¡¯s) and was introduced in 1969. ... The path to Ibuprofen¡¯s discovery is lined with many failures. Several different molecules were used in clinical trials, most of which produced unwanted side effects, Ibuprofen succeeded. ...
Ibufenac
Over the next few years, several phenylpropionic acids were investigated before Ibuprofen was selected for clinical trials. ... Ibuprofen was made available for prescription use in the U. ...
Synthesis:
Prepare Ibuprofen starting with 4-Isobutylacetophenone and react with Trimethylsulfonium Iodide to form an Epoxide. ... Ibuprofen is then formed.
Properties and Advantages:
Ibuprofen has 3 major types of effect on the body:
1. ... Prostaglandins are produced by an enzyme called arachidonate cyclo-oxygenase (COX), Ibuprofen works by inhibiting this enzyme thus inhibiting the production of prostaglandins which then reduces inflammation. ... Analgesic effect:
Ibuprofen is mainly effective against pain associated with inflammation or tissue damage. This is because prostaglandin¡¯s in an inflammation reaction causes pressure receptors in the inflamed area to be compressed which causes pain, as Ibuprofen inhibits the enzymes which produces prostaglandins, pain is reduced. ... Ibuprofen resets this centre in the hypothalamus, then the temperature-regulating mechanisms e. ... Ibuprofen works by inhibiting prostaglandin production in the hypothalamus, therefore, effectively reducing body temperature.
Other advantages of Ibuprofen are that it has the least side effects compared to other NSAID¡¯s. ... Ibuprofen can be used to treat headaches, colds and flu, rheumatic pain, muscular pain, backache, feverishness, migraine and period pain.
Approximate Word count = 1242
Approximate Pages = 5
(250 words per page double spaced)
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