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	1. effects on heart

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	ACh effect on heart
	Acetylcholine (ACh) was a common neurotransmitter that released by postganglionic fibers of the vagus nerve in the autonomic nervous system, mainly in the parasympathetic nerve towards the heart. ACh were expected to decrease the heart rate. The mechanism started with the ACh diffused and bound to the sacrolemma-related cholinergic muscarinic receptors, consisting Јi, Ј] and Ј^ subunits. ... Besides, the Ј]-Ј^ complex opened the ACh-activated potassium channels by phospholipase A2. This decreased the rate of pre-potential formation and the hyperpolarization process to be slower, creating the bradycardia condition, the decrease in heart rate. ... 1 mg/ml) of ACh added directly onto the heart surface initially could produce a slightly decreasing effect on heart rate rather than an increase. Approximate Word count = 485 Approximate Pages = 1.9 (250 words per page double spaced)

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