The cat and the mat
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I once saw a cat it sat on a mat
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To personalise this newsletter please visit the All adhesion molecules are integral membrane proteins that have cytoplasmic, transmembrane and extracellular domains. The cytoplasmic tail often interacts with cytoskeletal proteins which serve as the actual anchor within the cell. The extracellular domains of adhesion molecules extend from the cell and bind to other cells or matrix by binding to other adhesion molecules of the same type known as homophilic binding, binding to other adhesion molecules of a different type called heterophilic binding or binding to an intermediary 'linker' which itself binds to other adhesion molecules.
Types of adhesion molecules
There are four major families of cell adhesion molecules. These are the immunoglobulin (Ig) superfamily cell adhesion molecules, integrins, cadherins, and selectins.
Ig superfamily CAMs
The Ig superfamily CAMs are calcium-independent transmembrane glycoproteins. The best-studied members of this group are the neural cell adhesion molecules (N-CAMs) which are expressed predominantly in nervous tissue and the intercellular cell adhesion molecules (ICAMs)...