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	immunology
	T cell maturation occurs in the thymus. The earliest thymocytes lack detectable CD4 and CD8 and are referred to as double nefative cells. Those thymocytes that make a productive rearrangement of the gamma-deta TCR genes develop into CD4-, CD8-, CD3+ gamma-deta T cells, which account for only a small minority of thymocytes. The majority of double-negative thymocytes rearrange the alpha-beta TCR genes and develop into CD4+, CD3+ alpha-beta T cells or CD8+, CD3+ alpha-beta T cells. A repertoires of thymocytes with appropriate TCR specificities is shaped by two critical selection processes. One of these is the positive selection of all thymocytes bearing receptors that can bind a self-MHC molecules. Approximate Word count = 409 Approximate Pages = 1.6 (250 words per page double spaced)

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