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N-ethyl-N-nitrosurea (ENU) is the most power mutagen in mice. ... Therefore ENU acts through alkylation of nucleic acid without the need of metabolic activation. The ethyl group of the ENU is transferred to the nucleophilic sit on the nitrogen or oxygen of the nucleic acids predominantly the adenine and thiamine. ... The highest mutation rate occur within the spermatogonial stem cells obtaining a mutation in a single gene of choice in 1 out of every 175-655 gametes (Justice Mutagenesis ENU) Because of its power in isolating mutation in any gene or region of interest ENU is a powerful tool. ... Hence this make ENU a ideal mutagen because it leads to point mutation unlike radiation or other mutagenic agents such as chlorabrutial that induce deletion and inversion more often involving more that one gene.
Approximate Word count = 635
Approximate Pages = 2.5
(250 words per page double spaced)
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