The biggest event
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The biggest event of the British racing calendar is the
Grand National, run every April by such a large number
of horses that most punters who know their game steer
well clear of trying to pick a winner. It's a spectacle,
rather than a good place to do business. Faced with a
rather similar overabundance of choice, every month, in
our Highlights section, we seek to turn the spotlight
onto the best recent papers in drug discovery, briefly
and simply explaining their findings and relevance.
Hopefully, our methods for picking papers are more
rigorous than those of the average tipster. So how do we
choose what to highlight?
It is hard to define what limits to set to the field of
'drug discovery'.With practically every other paper in
biomedical science containing the almost obligatory
final sentence suggesting the therapeutic relevance of
the molecule or system under study, it sometimes seems
that almost everything falls within this remit. Clearly,
even those studies that seem unrelated to drugs might
impact the discovery of new therapeutics in some
unforeseen way. Certainly, papers published across a
wide array of journals, on many different topics, form
the backdrop to the discovery of new drugs. Our task is
to sift out those studies that are actually most likely to
advance the process, rather than those that indicate
with biologists, and the success rate of taking those candidates
into studies in humans is likely to improve only if
clinicians and basic scientists are talking the same language...